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This report describes ongoing efforts at the Lister Hill National Center for Biomedical Communications and the National Library of Medicine to promote, advance, and to provide leadership in non-text, data-intensive informatics. This program concentrates heavily on information science surrounding image data of 2, 3, and higher dimensions. Our mission reaches beyond high dimensional image processing or medical computer graphics; it attempts to synthesize semantic information and dynamic user navigation with visualizations created from real medical data. In the cases where we use models of biological structures, all of these models are generated from sources of real data, firmly grounding this work in the practical aspects of medicine. To adequately describe this research area, we have coined the new term, 3D Informatics, to encompass the blended notions of information science and medical visualization.