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Comparing Deep Learning Models for Multi-cell Classification in Liquid- based Cervical Cytology Image.

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Sornapudi S, Brown G, Xue Z, Long LR, Allen L, Antani SK
AMIA Annu Symp Proc. 2019; 2019: 820–827.
Abstract: 

Liquid-based cytology (LBC) is a reliable automated technique for the screening of Papanicolaou (Pap) smear data. It is an effective technique for collecting a majority of the cervical cells and aiding cytopathologists in locating abnormal cells. Most methods published in the research literature rely on accurate cell segmentation as a prior, which remains challenging due to a variety of factors, e.g., stain consistency, presence of clustered cells, etc. We propose a method for automatic classification of cervical slide images through generation of labeled cervical patch data and extracting deep hierarchical features by fine-tuning convolution neural networks, as well as a novel graph-based cell detection approach for cellular level evaluation. The results show that the proposed pipeline can classify images of both single cell and overlapping cells. The VGG-19 model is found to be the best at classifying the cervical cytology patch data with 95 % accuracy under precision-recall curve.

Sornapudi S, Brown G, Xue Z, Long LR, Allen L, Antani SK. Comparing Deep Learning Models for Multi-cell Classification in Liquid- based Cervical Cytology Image. AMIA Annu Symp Proc. 2019; 2019: 820–827.