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Investigating drug classes in biomedical terminologies from the perspective of clinical decision support.

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AMIA Annu Symp Proc. 2010 Nov 13;2010:56-60.
Abstract: 

OBJECTIVES

To assess whether 1) the necessary drug classes and 2) the necessary drug-class membership relations are represented in biomedical terminologies in order to support clinical decision regarding drug-drug interactions.

METHODS

In order to investigate drug classes and drug-class membership in clinical terminologies, we start by establishing a reference list of these entities. Then, we map drugs and classes to the UMLS, where we investigate their relations.

RESULTS

186 (83%) of the 223 names for drug classes mapped to the UMLS. The single best source is SNOMED CT with 75%. 140 (89%) of the 157 drug-membership relations were found in the UMLS.

CONCLUSIONS

One important category of drug classes missing from all clinical terminologies is related to drug metabolism by the Cytochrome P450 enzyme family.

Bodenreider O, Demner-Fushman D. Investigating drug classes in biomedical terminologies from the perspective of clinical decision support. AMIA Annu Symp Proc. 2010 Nov 13;2010:56-60.