Interactive Publications are scientific multimedia documents that give readers more information from an article than is available in the published form (electronic or print) by enabling interaction with the included media (tables, graphs, images, videos, biomedical image studies, etc.) LHNCBC conducts research into models for highly interactive multimedia documents that could transform the next generation of publishing in biomedicine. We focus on the standards, formats, authoring and reading tools necessary for the creation and use of such interactive publications that, in addition to text, contain media objects relevant to biomedical research and clinical practice: video, audio, bitmapped images, interactive tables and graphs, and clinical DICOM images such as x-rays, CT, MRI, and ultrasound.