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Imaging Tools for Cancer Research

The goal of our work in Biomedical Imaging is two-fold: One, to develop advanced imaging tools for biomedical research in partnership with the National Cancer Institute and other organizations. Secondly, to conduct research in Content Based Image Retrieval (CBIR) to index and retrieve medical images by image features (e.g., shape, color and texture), augmented by textual features as well. This work includes the development of the CervigramFinder for retrieval of uterine cervix images by image features, SPIRS for retrieval of digitized x-ray images of the spine from NHANES II and a distributed global system (SPIRS-IRMA) for image retrieval by both high-level and detailed features of medical images, in collaboration with Aachen University, Germany.

CBIR is also an aspect of the Image Text Indexing (ITI) project that seeks to automatically index illustrations in medical articles by processing text in figure captions and mentions in the article, as well as image features in the illustrations.

Publications/Tools: 
KC S, Wendling L, Antani SK, Thoma GR. Scalable arrow detection in biomedical images. Pattern Recognition (ICPR), 2014 22nd International Conference; pp 3257-62. DOI: 10.1109/ICPR.2014.561
You D, Antani SK, Demner-Fushman D, Thoma GR. A MRF Model for Biomedical Image Segmentation. CBMS 2014. May 2014.
You D, Antani SK, Demner-Fushman D, Thoma GR. A Contour-based Shape Descriptor For Biomedical Image Classification and Retrieval. Proceedings of SPIE 2014, Vol. 9021, Document Recognition and Retrieval XXI. February 2014;9021.
Karargyris A, Rondonotti E, Mandelli G, Koulaouzidis A. Evaluation of 4 three-dimensional representation algorithms in capsule endoscopy images. World J Gastroenterol. 2013 Nov 28;19(44):8028-33. doi: 10.3748/wjg.v19.i44.8028.
You D, Antani SK, Demner-Fushman D, Thoma GR. Does figure-text improve biomedical image retrieval? NIH Intramural Research Festival, Bethesda MD, November 6-8, 2013.
Karargyris A, Koulaouzidis A. Capsule-odometer: a concept to improve accurate lesion localisation. World J Gastroenterol. 2013 Sep 21;19(35):5943-6. doi: 10.3748/wjg.v19.i35.5943.
Bryant B, Sari-Sarraf H, Wachtel M, Long LR, Antani SK. Fast GPU-based segmentation of H&E stained squamous epithelium from multi-gigapixel tiled virtual slides Proc. SPIE 8676, Medical Imaging 2013: Digital Pathology, 86760X (March 29, 2013); doi:10.1117/12.2007800
Jaeger S. An information-theoretic neural model based on concepts in Chinese medicine. 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW).
He L, Long LR, Antani SK, Thoma GR. Histology image analysis for carcinoma detection and grading. Comput Methods Programs Biomed. 2012 Sep;107(3):538-56. doi: 10.1016/j.cmpb.2011.12.007. Epub 2012 Mar 20.
Xue Z, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Window classification of brain CT images in biomedical articles. AMIA Annu Symp Proc. 2012;2012:1023-9. Epub 2012 Nov 3.

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