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Imaging Tools for Cancer Research

Screenshot of the Boundary Marking Tool created for cancer research.
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The goal of our work in Biomedical Imaging is two-fold: One, to develop advanced imaging tools for biomedical research in partnership with the National Cancer Institute and other organizations. Secondly, to conduct research in Content Based Image Retrieval (CBIR) to index and retrieve medical images by image features (e.g., shape, color and texture), augmented by textual features as well. This work includes the development of the CervigramFinder for retrieval of uterine cervix images by image features, SPIRS for retrieval of digitized x-ray images of the spine from NHANES II and a distributed global system SPIRS-IRMA for image retrieval by both high-level and detailed features of medical images, in collaboration with Aachen University, Germany.

CBIR is also an aspect of the Image Text Indexing (ITI) project that seeks to automatically index illustrations in medical articles by processing text in figure captions and mentions in the article, as well as image features in the illustrations.

Candemir S, Antani SK. A review on lung boundary detection in chest X-rays. Int J Comput Assist Radiol Surg. 2019 Feb 7. doi: 10.1007/s11548-019-01917-1.
Hu L, Bell D, Antani SK, Xue Z, Yu K, Horning MP, Gachuhi N, Wilson B, Jaiswal MS, Befano B, Long LR, Herrero R, Einstein MH, Burk RD, Demarco M, Gage JC, Wentzensen N, Schiffman M. An Observational Study of Deep Learning and Automated Evaluation of Cervical Images for Cancer Screening. J Natl Cancer Inst. 2019 Jan 10. doi: 10.1093/jnci/djy225
Poostchi M, Ilker E, McMenamin K, Gordon E, Palaniappan N, Pierce S, Maude RJ, Bansal A, Srinivasan P, Miller L, Palaniappan K, Thoma GR, Jaeger S. Malaria parasite detection and cell counting for human and mouse using thin blood smear microscopy. J Med Imaging (Bellingham). 2018 Oct;5(4):044506. doi: 10.1117/1.JMI.5.4.044506. Epub 2018 Dec 12.
Moallem G, Sari-Sarraf H, Poostchi Mohammadabadi M, Maude R, Silamut K, Antani SK, Jaeger S. Detecting and segmenting overlapping red blood cells in microscopic images of thin blood smears. SPIE Medical Imaging, 2018.
Xue Z, Rajaraman S, Long LR, Antani SK, Thoma GR. Gender Detection from Spine X-ray Images Using Deep Learning. Proc. IEEE International Symposium on Computer-Based Medical Systems (CBMS), Karlstad, Sweden, 2018. pp. 54-58, DOI:10.1109/CBMS.2018.00017.
Sornapudi S, Stanley RJ, Stoecker WV, Almubarak H, Long LR, Antani SK, Thoma GR, Zuna R, Frazier SR. Deep Learning Nuclei Detection in Digitized Histology Images by Superpixels. J Pathol Inform. 2018 Mar 5;9:5. doi: 10.4103/jpi.jpi_74_17. eCollection 2018.
Santosh KC, Antani SK. Automated chest x-ray screening: Can lung region symmetry help detect pulmonary abnormalities? doi: 10.1109/TMI.2017.2775636 vol. 37, no. 5, 1168-1177.
Xue Z, Antani SK, Long LR, Thoma GR. Using deep learning for detecting gender in adult chest radiographs. Proc SPIE 10579, Medical Imaging 2018: Imaging Informatics for Healthcare, Research, and Applications, 105790D (6 March 2018) pp. doi: 10.1117/12.2293027.
Xue Z, Jaeger S, Antani SK, Long LR, Karargyris A, Siegelman J, Folio L, Thoma GR. Localizing tuberculosis in chest radiographs with deep learning. Proc SPIE 10579, Medical Imaging 2018: Imaging Informatics for Healthcare, Research, and Applications, 105790U (6 March 2018) pp. doi: 10.1117/12.2293022
Almubarak H, Guo P, Stanley RJ, Long LR, Antani SK, Thoma GR. Algorithm Enhancements for Improvement of Localized Classification of Uterine Cervical Cancer Digital Histology Images. in Handbook of Research on Emerging Perspectives on Healthcare Information Systems and Informatics,. IGI Global (Hershey, PA).