PERSONNEL

MISSING

Zhiyun Xue, PhD

Computational Health Research Branch

Contact Information
Building 38A - Lister Hill Center, 10S1008
301.827.4939
zhiyun.xue@nih.gov


Expertise and Research Interests:

Dr. Zhiyun (Jaylene) Xue is a Staff Scientist at the Lister Hill National Center for Biomedical Communications (LHC) at the National Library of Medicine (NLM). She obtained her Ph.D. from Lehigh University USA, M.S. and B.S. from Tsinghua University, China. Dr. Xue has been working at LHC since 2006 on a number of medical imaging informatics projects. By applying her knowledge and expertise in the fields of machine learning, image processing, and computer vision to analyze biomedical images in different modalities, Dr. Xue puts her R&D efforts in those projects with the goals of advancing the research in biomedical informatics and data science, assisting clinicians at the point-of-care, improving the health of the people, and addressing the needs of the underserved population. One project she is passionate about and is currently devoting herself to is the project of automatic image analysis for cervical cancer screening, which aims to reduce the mortality of cervical cancer, one of the most common cancers among women.

Honors and Awards:

Dr. Xue received the HHS Ignite Group Award in 2014, the NLM Special Acts/Services Group Award in 2011-2014 and 2017-2019.


Publications:

Angara S, Guo P, Xue Z, Antani S. Semi-Supervised Learning for Cervical Precancer Detection. 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS), 2021, pp. 202-206, doi: 10.1109/CBMS52027.2021.00072.

Xue Z, Guo P, Desai K, Pal A, Ajenifuja KO, Adepiti CA, Long LR, Schiffman M, Antani S. A Deep Clustering Method for Analyzing Uterine Cervix Images Across Imaging Devices. 34th IEEE International Symposium on Computer-Based Medical Systems (CBMS), June 2021, pp. 527-532, doi: 10.1109/CBMS52027.2021.00085.

Guo P, Xue Z, Jeronimo J, Gage JC, Desai KT, Befano B, García F, Long LR, Schiffman M, Antani S. Network Visualization and Pyramidal Feature Comparison for Ablative Treatability Classification Using Digitized Cervix Images. J Clin Med. 2021 Mar 1;10(5):953. doi: 10.3390/jcm10050953.

Desai KT, Ajenifuja KO, Banjo A, Adepiti CA, Novetsky A, Sebag C, Einstein MH, Oyinloye T, Litwin TR, Horning M, Olanrewaju FO, Oripelaye MM, Afolabi E, Odujoko OO, Castle PE, Antani S, Wilson B, Hu L, Mehanian C, Demarco M, Gage JC, Xue Z, Long LR, Cheung L, Egemen D, Wentzensen N, Schiffman M. Design and feasibility of a novel program of cervical screening in Nigeria: self-sampled HPV testing paired with visual triage. Infect Agent Cancer. 2020 Oct 14;15:60. doi: 10.1186/s13027-020-00324-5.

Ye J, Xue Y, Long LR, Antani S, Xue Z, Cheng K, Huang X. Synthetic Sample Selection via Reinforcement Learning. In: Martel A.L. et al. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. MICCAI 2020. Lecture Notes in Computer Science, vol 12261. Springer, Cham. https://doi.org/10.1007/978-3-030-59710-8_6.

Pal A, Xue Z, Befano B, Rodriguez AC, Long L, Schiffman M, Antani SK. Deep Metric Learning for Cervical Image Classification. IEEE Access, vol. 9, pp. 53266-53275, 2021, doi: 10.1109/ACCESS.2021.3069346.

Guo P, Xue Z, Mtema Z, Yeates K, Ginsburg O, Demarco M, Long LR, Schiffman M, Antani SK. 2. Ensemble Deep Learning for Cervix Image Selection toward Improving Reliability in Automated Cervical Precancer Screening. Diagnostics (Basel) 2020 Jul 3;10(7):451.

Xue Z, Novetsky A, Einstein M, Marcus J, Befano B, Guo P, Demarco M, Wenzenten N, Long LR, Schiffman M, Antani SK. A demonstration of automated visual evaluation of cervical images taken with a smartphone camera. Int J Cancer. 2020 Apr 30.

Sornapudi S, Brown G, Xue Z, Long LR, Allen L, Antani SK. Comparing Deep Learning Models for Multi-cell Classification in Liquid- based Cervical Cytology Image. AMIA Annu Symp Proc. 2019; 2019: 820–827.

Guo P, Xue Z, Long LR, Antani SK. Anatomical landmark segmentation in uterine cervix images using deep learning. Proc. SPIE 11318, Medical Imaging 2020: Imaging Informatics for Healthcare, Research, and Applications, 1131810 (2 March 2020)

Zou J, Xue Z, Brown G, Long LR, Antani SK. Deep learning for nuclei segmentation and cell classification in cervical liquid based cytology. Proc. SPIE 11318, Medical Imaging 2020: Imaging Informatics for Healthcare, Research, and Applications, 1131811 (2 March 2020); doi: 10.1117/12.2549547

Guo P, Xue Z, Long LR, Antani SK. Cross-Dataset Evaluation of Deep Learning Networks for Uterine Cervix Segmentation. Diagnostics (Basel). 2020 Jan 14;10(1). pii: E44. doi: 10.3390/diagnostics10010044.

Rajaraman S, Candemir S, Xue Z, Alderson P, Thoma G, Antani SK. A Novel Stacked Model Ensemble for Improved TB Detection in Chest Radiographs. In Santosh KC et al. (Eds.). Medical Imaging: Artificial Intelligence, Image Recognition, and Machine Learning Techniques. (pp. 1-26). New York, NY: CRC Press, Taylor & Francis Group.

Xue Y, Zhou Q, Ye J, Long LR, Antani SK, Cornwell C, Xue Z, Huang X. Synthetic Augmentation and Feature-based Filtering for Improved Cervical Histopathology Image Classification. ArXiv, abs/1907.10655.

Ganesan P, Xue Z, Singh S, Long LR, Ghoraani B, Antani SK. Performance Evaluation of a Generative Adversarial Network for Deblurring Mobile-phone Cervical Images. Proc. IEEE Engineering in Medicine and Biology Conference (EMBC), Berlin, Germany, 23 – 27 July 2019. pp. 4487 – 4490.

Guo P, Singh S, Xue Z, Long LR, Antani SK. Deep Learning for Assessing Image Focus for Automated Cervical Cancer Screening. 2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI) DOI: 10.1109/BHI.2019.8834495.

Hu L, Bell D, Antani SK, Xue Z, Yu K, Horning MP, Gachuhi N, Wilson B, Jaiswal MS, Befano B, Long LR, Herrero R, Einstein MH, Burk RD, Demarco M, Gage JC, Wentzensen N, Schiffman M. An Observational Study of Deep Learning and Automated Evaluation of Cervical Images for Cancer Screening. J Natl Cancer Inst. 2019 Jan 10. doi: 10.1093/jnci/djy225

Vajda S, Karargyris A, Jaeger S, Santosh KC, Candemir S, Xue Z, Antani SK, Thoma GR. Feature Selection for Automatic Tuberculosis Screening in Frontal Chest Radiographs. J Med Syst. 2018 Jun 29;42(8):146. doi: 10.1007/s10916-018-0991-9.

Xue Z, Long LR, Jaeger S, Folio L, Thoma GR. Extraction of Aortic Knuckle Contour in Chest Radiographs Using Deep Learning. EMBC 2018.

Rajaraman S, Candemir S, Xue Z, Alderson P, Kohli M, Abuya J, Thoma GR, Antani SK. A novel stacked generalization of models for improved TB detection in chest radiographs. Proc. IEEE Engineering in Medicine and Biology Conference (EMBC 2018), Honolulu, Hawaii, 2018. pp. 718-721.

Xue Z, Rajaraman S, Long LR, Antani SK, Thoma GR. Gender Detection from Spine X-ray Images Using Deep Learning. Proc. IEEE International Symposium on Computer-Based Medical Systems (CBMS), Karlstad, Sweden, 2018. pp. 54-58, DOI:10.1109/CBMS.2018.00017.

Fung K, Xue Z, Ameye F, Gutierrez AR, D'Have A. Achieving Logical Equivalence between SNOMED CT and ICD-10-PCS Surgical Procedures. AMIA Annu Symp Proc. 2018 Apr 16;2017:724-733. eCollection 2017.

Xue Z, Antani SK, Long LR, Thoma GR. Using deep learning for detecting gender in adult chest radiographs. Proc SPIE 10579, Medical Imaging 2018: Imaging Informatics for Healthcare, Research, and Applications, 105790D (6 March 2018) pp. doi: 10.1117/12.2293027.

Xue Z, Jaeger S, Antani SK, Long LR, Karargyris A, Siegelman J, Folio L, Thoma GR. Localizing tuberculosis in chest radiographs with deep learning. . Proc SPIE 10579, Medical Imaging 2018: Imaging Informatics for Healthcare, Research, and Applications, 105790U (6 March 2018) pp. doi: 10.1117/12.2293022

Rajaraman S, Antani SK, Candemir S, Xue Z, Abuya J, Kohli M, Alderson P, Thoma GR. Comparing deep learning models for population screening using chest radiography. Proc. SPIE 10575, Medical Imaging 2018: Computer-Aided Diagnosis, 105751E (27 February 2018).

Xue Z, Antani SK, Long LR, Thoma GR. Using deep learning for detecting gender in adult chest radiographs. SPIE Medical Imaging 2018

Xue Z, Jaeger S, Antani SK, Long LR, Karargyris A, Siegelman J, Folio LR, Thoma GR. Localizing tuberculosis in chest radiographs with deep learning. SPIE Medical Imaging 2018

Rajaraman S, Antani SK, Xue Z, Candemir S, Jaeger S, Thoma GR. Visualizing abnormalities in chest radiographs through salient network activations in Deep Learning. Proc. IEEE Life Sciences Conference (LSC), Sydney, Australia, 2017. pp. 71-74, DOI:10.1109/LSC.2017.8268146.

Candemir S, Antani SK, Xue Z, Thoma GR. Novel Method for Storyboarding Biomedical Videos for Medical Informatics. 30th IEEE International Symposium on Computer-Based Medical Systems

Xue Z, Antani SK, Long LR, Thoma GR. Automatic multi-label annotation of abdominal CT images using CBIR. Proc. SPIE 10138, Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications, 1013807 (March 13, 2017); doi:10.1117/12.2254368.

Ding M, Antani SK, Jaeger S, Xue Z, Candemir S, Kohli M, Thoma GR. Local-Global Classifier Fusion for Screening Chest Radiographs. Proc. SPIE 10138, Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications, 101380A (March 13, 2017); doi:10.1117/12.2252459

Xue Z, Rahman M, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Modality Classification for Searching Figures in Biomedical Literature. Proceedings of the IEEE 29th International Symposium on Computer-Based Medical Systems, pp. 152-157, 2016. doi:10.1109/CBMS.2016.29.

Xu T, Zhang H, Xin C, Kim E, Long LR, Xue Z, Antani SK, Huang Z. Multi-feature based Benchmark for Cervical Dysplasia Classification Evaluation. Pattern Recognition. ISSN 0031-3203, DOI: 10.1016/j.patcog.2016.09.027.

Xue Z, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Improving face image extraction by using deep learning technique. Proc. SPIE 9789, Medical Imaging 2016: PACS and Imaging Informatics: Next Generation and Innovations, 97890J (March 25, 2016); doi:10.1117/12.2216278.

Candemir S, Jaeger S, Lin W, Xue Z, Antani SK, Thoma GR. Automatic heart localization and radiographic index computation in chest x-rays. Proc. SPIE. 9785, Medical Imaging 2016: Computer-Aided Diagnosis, 978517. DOI: 10.1117/12.2217209.

Karargyris A, Siegelman J, Tzortzis D, Jaeger S, Candemir S, Xue Z, KC S, Vajda S, Antani SK, Folio L, Thoma GR. Combination of texture and shape features to detect pulmonary abnormalities in digital chest X-rays. Int J Comput Assist Radiol Surg. 2016 Jan;11(1):99-106. doi: 10.1007/s11548-015-1242-x. Epub 2015 Jun 20.

Xue Z, Candemir S, Antani SK, Long LR, Jaeger S, Demner-Fushman D, Thoma GR. Foreign Object Detection in Chest X-rays. Proc IEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2015, International Workshop on Biomedical and Health Informatics, Bethesda, Maryland, Nov. 9-12, 2015, pp: 56-61.

Xu T, Xin C, Long LR, Antani SK, Xue Z, Kim E, Huang X. A New Image Data Set and Benchmark for Cervical Dysplasia Classification Evaluation. Machine Learning in Medical Imaging: 6th International Workshop, MLMI 2015, LNCS 9352, pp. 26–35, 2015. DOI: 10.1007/978-3-319-24888-2 4.

Xue Z, You D, Candemir S, Jaeger S, Antani SK, Long LR, Thoma GR. Chest X-ray Image View Classification. The 28th IEEE International Symposium on Computer-Based Medical Systems

Xue Z, You D, Chachra S, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Extraction of endoscopic images for biomedical figure classification. Proc. SPIE. 9418, Medical Imaging 2015: PACS and Imaging Informatics: Next Generation and Innovations, 94180P. (March 17, 2015) doi: 10.1117/12.2081033.

KC S, Xue Z, Antani SK, Thoma GR. NLM at ImageCLEF 2015: Biomedical Multipanel Figure Separation. Editors: Cappellato, L., Ferro, N., Jones, G., and San Juan, E., CLEF 2015 Labs and Workshops, Notebook Papers. CEUR WorkshopProceedings (CEUR-WS.org), ISSN 1613-0073, http://ceur-ws.org/ Vol-1391/.

Simpson MS, You D, Rahman MM, Xue Z, Demner-Fushman D, Antani S, Thoma G. Literature-based biomedical image classification and retrieval. Comput Med Imaging Graph. 2015 Jan;39:3-13. doi: 10.1016/j.compmedimag.2014.06.006. Epub 2014 Jun 20.

Xue Z, Bryant B, Long LR, Sari-Sarraf H, Thoma GR, Wachtel M. A Client-Server Tool for Automatic Fast GPU-based Detection of Squamous Epithelium Tissue Regions in Histology Images [Poster]. RSNA 2014. Chicago, USA, Nov 30-Dec 5, 2014

Xue Z, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Body Segment Classification for Visible Human Cross Section Slices. IEEE 27th International Symposium on Computer-Based Medical Systems (CBMS), New York, NY, May 2014: pp. 199-204

Xue Z, You D, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Classification of Visual Signs in Abdominal CT Image Figures in Biomedical Literature. Proc. SPIE. 9039. Medical Imaging 2014: PACS and Imaging Informatics: Next Generation and Innovations. 90390T.

Jaeger S, Karargyris A, Candemir S, Folio L, Siegelman J, Callaghan FM, Xue Z, Palaniappan K, Singh RK, Antani SK, Thoma GR, Wang, Lu P, McDonald CJ. Automatic tuberculosis screening using chest radiographs. IEEE Trans Med Imaging. 2014 Feb;33(2):233-45. doi: 10.1109/TMI.2013.2284099. Epub 2013 Oct 1.

Candemir S, Jaeger S, Palaniappan K, Musco J, Singh RK, Xue Z, Karargyris A, Antani SK, Thoma GR, McDonald CJ. Lung segmentation in chest radiographs using anatomical atlases with nonrigid registration. IEEE Trans Med Imaging. 2014 Feb;33(2):577-90. doi: 10.1109/TMI.2013.2290491. Epub 2013 Nov 13.

Chachra S, Xue Z, Antani SK, Demner-Fushman D, Thoma GR. Extraction and Labeling High-resolution Images from PDF Documents. Proc. SPIE 9021, Document Recognition and Retrieval XXI, 90210Q (December 27, 2013). doi:10.1117/12.2042336.

Karargyris A, Candemir S, Jaeger S, Xue Z, Antani SK, Thoma GR. A Combined Approach for Lung Boundary Segmentation of Chest X-Ray Images [Poster]. NIH Intramural Research Festival, Bethesda MD, November 6-8, 2013.

Xue Z, Jaeger S, Karargyris A, Candemir S, Antani SK, Long LR, Thoma GR, McDonald CJ. A System for Automated Screening for Tuberculosis using Digital Chest X-rays for Resources-Constrained Regions [Poster]. NIH Intramural Research Festival, Bethesda MD, November 6-8, 2013.

Karargyris A, Folio L, Siegelman J, Callaghan FM, Candemir S, Xue Z, Lu P-X, Wang, Antani SK, Thoma GR, Jaeger S. Comparing the Performance of Man and Machine for TB Screening in Chest Radiographs [Poster]. NIH Intramural Research Festival, Bethesda MD, November 6-8, 2013.

Xue Z, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Classification of CT Figures in Biomedical Articles Based on Body Segments. 2013 IEEE International Conference on Healthcare Informatics (ICHI), pp.264,268, 9-11 Sept. 2013. doi: 10.1109/ICHI.2013.17.

Apostolova E, You D, Xue Z, Antani SK, Demner-Fushman D, Thoma GR. Image Retrieval From Scientific Publications: Text and Image Content Processing To Separate Multipanel Figures. JASIST (Journal of the American Society for Information Science and Technology), 64(5):893–908, 2013.

Xue Z, Antani SK, Long LR, Demner-Fushman D, Thoma GR. Window classification of brain CT images in biomedical articles. AMIA Annu Symp Proc. 2012;2012:1023-9. Epub 2012 Nov 3.

Xue Z, Long LR, Antani SK, Thoma GR. Spine x-ray image retrieval using partial vertebral boundaries. 24th International Symposium on Computer-Based Medical Systems. Bristol, UK. June 2011.

Xue Z, Long LR, Antani SK, Thoma GR. Pathology-based vertebral image retrieval. Proceedings of the 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2011, March 30 - April 2, 2011, Chicago, Illinois, USA. pages 1893-1896, IEEE, 2011. doi: 10.1109/ISBI.2011.5872778.

Antani S, Xue Z, Long LR, Bennett D, Ward S, Thoma GR. Is there a need for biomedical CBIR systems in clinical practice? Outcomes from a usability study. Proceedings of SPIE Medical Imaging 2011: Advanced PACS-based Imaging Informatics and Therapeutic Applications. Orlando, FL. February 2011;7967:796708.

Xue Z, Long LR, Antani SK, Neve L, Zhu Y, Thoma GR. A unified set of analysis tools for uterine cervix image segmentation. Comput Med Imaging Graph. 2010 Dec;34(8):593-604. doi: 10.1016/j.compmedimag.2010.04.002. Epub 2010 May 26.

Xue Z, Antani SK, Long LR, Thoma GR. An online segmentation tool for cervicographic image analysis. ACM International Health Informatics Symposium, IHI 2010, Arlington, VA, USA, November 11 - 12, 2010, Proceedings; 01/2010.

Xue Z, Long LR, Antani SK, Thoma GR. Automatic Extraction of Mosaic Patterns In Uterine Cervix Images. 23rd IEEE International Symposium on Computer-Based Medical Systems (CBMS) 2010. Perth, Australia. October 2010:273-8.

Xue Z, Antani S, Long LR, Thoma GR. Web-accessible Cervigram Automatic Segmentation Tool. SPIE Medical Imaging Conference. March 2010;7628

Xue Z, Long LR, Antani SK, Jeronimo J, Thoma GR. Image-retrieval System Aids Cervical Cancer Studies. SPIE Newsroom. April 2009

Xue Z, Long LR, Antani SK, Jeronimo J, Thoma GR. Segmentation of Mosaicism in Cervicographic Images Using Support Vector Machines. Proc. SPIE 7259, Medical Imaging 2009, Lake Buena Vista, Florida, United States: Image Processing, 72594X (27 March 2009); doi: 10.1117/12.812318; http://dx.doi.org/10.1117/12.812318.

Zhu Y, Huang X, Wang W, Lopresti D, Long LR, Antani SA, Xue Z, Thoma GR. Balancing the Role of Priors in Multi-Observer Segmentation Evaluation. J Signal Process Syst. 2008 May 28;55(1-3):185-207

Huang X, Wang W, Xue Z, Antani SK, Long LR, Jeronimo J. Tissue Classification using Cluster Features for Lesion Detection in Digital Cervigrams. Proc. SPIE Medical Imaging 2008. April 2008;6914:69141Z-1-8

Xue Z, Long R, Antani SK, Thoma GR. A Web-accessible Content-based Cervicographic Image Retrieval System. Proc SPIE Medical Imaging 2008. April 2008;6919:691907-1-9

Xue Z, Antani SK, Long LR, Thoma GR. Comparative Performance Analysis of Cervix ROI Extraction and Specular Reflection Removal Algorithms for Uterine Cervix Image Analysis. Proc SPIE Medical Imaging 2007. Vol. 6512: 65124I-1-9

Xue Z, Antani S, Long LR, Jeronimo J, Thoma GR. Investigating CBIR Techniques for Cervicographic Images. AMIA Annu Symp Proc. 2007 Oct 11:826-30.

Zhu Y, Long LR, Antani S, Xue Z, Thoma GR. Web-based STAPLE for Quality Estimation of Multiple Image Segmentations. Poster at 20th NIH Research Festival (IMAG-12), September 2007, National Institutes of Health