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High Resolution Electron Microscopy
The 3D informatics for High Resolution Electron Microscopy project is analyzing the life sciences at nanometer scales. It includes the following efforts:
- Researchers are examining data acquired from advanced microscopes that generate 3D data to provide new insights into the spatial relationships of sub-cellular mechanisms and a better understanding of systems biology. This work is being done in partnership with the National Cancer Institute Laboratory for Cell Biology.
- Computer scientists are doing high performance computing on commercial grade graphics hardware (GPUs) to accurately align and average sub-volumes of data generated from transmission electron tomography to achieve super-resolution that can illuminate protein structures as small as 10-20 angstroms. Researchers have applied these methods to study the glycoprotein trimeric spikes found on HIV viruses as well as those found on influenza virions.
- Through biomedical image analysis of data from ion-abrasion scanning electron microscopes, researchers are studying the mechanism by which cells infected with HIV communicate the virus to healthy cells, leading to better understanding of the disease's development. They are using these technologies to help fight cancer, influenza, HIV/AIDS, and other public health risks.
This work is joint with LHNCBC's Audiovisual Program and Development Branch.