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Imaging Tools for Cancer Research

The goal of our work in Biomedical Imaging is two-fold: One, to develop advanced imaging tools for biomedical research in partnership with the National Cancer Institute and other organizations. Secondly, to conduct research in Content Based Image Retrieval (CBIR) to index and retrieve medical images by image features (e.g., shape, color and texture), augmented by textual features as well. This work includes the development of the CervigramFinder for retrieval of uterine cervix images by image features, SPIRS for retrieval of digitized x-ray images of the spine from NHANES II and a distributed global system (SPIRS-IRMA) for image retrieval by both high-level and detailed features of medical images, in collaboration with Aachen University, Germany.

CBIR is also an aspect of the Image Text Indexing (ITI) project that seeks to automatically index illustrations in medical articles by processing text in figure captions and mentions in the article, as well as image features in the illustrations.

Publications/Tools: 
Vajda S, Karargyris A, Jaeger S, Santosh KC, Candemir S, Xue Z, Antani SK, Thoma GR. Feature Selection for Automatic Tuberculosis Screening in Frontal Chest Radiographs. J Med Syst. 2018 Jun 29;42(8):146. doi: 10.1007/s10916-018-0991-9.
Xue Z, Rajaraman S, Long LR, Antani SK, Thoma GR. Gender Detection from Spine X-ray Images Using Deep Learning. Proc. IEEE International Symposium on Computer-Based Medical Systems (CBMS), Karlstad, Sweden, 2018. pp. 54-58, DOI:10.1109/CBMS.2018.00017.
Sornapudi S, Stanley RJ, Stoecker WV, Almubarak H, Long LR, Antani SK, Thoma GR, Zuna R, Frazier SR. Deep Learning Nuclei Detection in Digitized Histology Images by Superpixels. J Pathol Inform. 2018 Mar 5;9:5. doi: 10.4103/jpi.jpi_74_17. eCollection 2018.
Zohora FT, Antani SK, Santosh KC. Circle-like foreign element detection in chest x-rays using normalized cross-correlation and unsupervised clustering. Proc. SPIE 10574, Medical Imaging 2018: Image Processing, 105741V (2 March 2018); doi: 10.1117/12.2293739; doi.org/10.1117/12.2293739.
Almubarak H, Guo P, Stanley RJ, Long LR, Antani SK, Thoma GR. Algorithm Enhancements for Improvement of Localized Classification of Uterine Cervical Cancer Digital Histology Images. in Handbook of Research on Emerging Perspectives on Healthcare Information Systems and Informatics,. IGI Global (Hershey, PA).
Bryant B, Sari-Sarraf H, Long LR, Antani SK. A Kernel Support Vector Machine Trained Using Approximate Global and Exhaustive Local Sampling. Proceedings of the 4th IEEE/ACM International Conference on Big Data Computing, Applications and Technologies (BDCAT) 2017, Austin, Texas, USA, December 2017. Pp. 267-8 DOI: https://doi.org/10.1145/3148055.3149206
de Herrera G, Long LR, Antani SK. Graph Representation for Content–based fMRI Activation Map Retrieval. Proceedings of 1st Life Sciences Conference, Sydney, Australia, December 2017 pp. 129-32 DOI: https://doi.org/10.1109/LSC.2017.8268160.
Almubarak HA, Stanley RJ, Long LR, Antani SK, Thoma GR, Zuna R, Frazier SR. Convolutional Neural Network Based Localized Classification of Uterine Cervical Cancer Digital Histology Images. Procedia Computer Science, Volume 114, 2017, Pages 281-287, ISSN 1877-0509, https://doi.org/10.1016/j.procs.2017.09.044.
Xu T, Zhang H, Xin C, Kim E, Long LR, Xue Z, Antani SK, Huang X. Multi-feature based Benchmark for Cervical Dysplasia Classification Evaluation. Pattern Recognit. 2017 Mar;63:468-475. doi: 10.1016/j.patcog.2016.09.027. Epub 2016 Sep 22.
KC S, Aafaque A, Antani SK, Thoma GR. Line Segment-Based Stitched Multipanel Figure Separation for Effective Biomedical CBIR. Int. J. Patt. Recogn. Artif. Intelligence 31, 1757003 (2017) https://doi.org/10.1142/S0218001417570038.

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