findDrugInteractions

Information returned: Interactions of an RxNorm drug
Service domain: https://rxnav.nlm.nih.gov
HTTP request: GET /REST/interaction/interaction.xml?rxcui=rxcui&sources=sources

Description

Get the drug interactions for a specified drug.

Upcoming Changes On or About January 2, 2024:

The Drug-Drug Interaction API will be discontinued on or about January 2, 2024. RxNav's Interactions tab will also be removed.

The RxNorm identifier can represent an ingredient (e.g. simvastatin), a brand name (e.g. Tylenol) or a branded or clinical drug (e.g. Morphine 50 mg oral tablet).

Currently, the API uses two sources for its interaction information - ONCHigh and DrugBank.

ONCHigh is a list of high-priority drug-drug interactions derived by a panel of experts and contained in a JAMIA article. ONCHigh is updated using CredibleMeds with drugs that have a known risk of Torsades de Pointes (TdP).

DrugBank drug-drug interaction information is drawn (unmodified) from the non-commercial version of the DrugBank database, which does not carry severity information. See the DrugBank license for more information.

Parameters

Parameter	Location	Use	Description	Default
format	Path	Optional	Notation for results One of: .xml Get results in XML .json Get results in JSON	.xml
rxcui	Query	Required	RxNorm identifier
sources	Query	Optional	Sources to use (if none specified, all sources will be used) (Space-separated list. See getInteractionSources for the menu.)	ALL

Parameter

Location

Use

Description

Default

format

Path

Optional

Notation for results

One of:

.xml: Get results in XML
.json: Get results in JSON

.xml

rxcui

Query

Required

RxNorm identifier

sources

Query

Optional

Sources to use (if none specified, all sources will be used)

(Space-separated list. See getInteractionSources for the menu.)

ALL

All query parameters are case-insensitive.

Note that HTTP requires that query parameters be "URL encoded". For instance, a "space-separated list" will, in practice, usually appear to use either a plus sign (+) or %20 as the separator. For full information on URL encoding, please refer to IETF RFC 3986, "Uniform Resource Identifier".

Output structure

Results are available as either XML or JSON.

The XML result has the root element interactiondata. It is described in the XML Schema for the Drug Interaction API; the relevant element structure is summarized below. Elements that would be empty might be left out.
The JSON result is an object {...}, analogous to the content of the XML interactiondata. Fields that might occur multiple times in the XML are expressed as an array. Fields that would be empty might be null or left out. Numbers are expressed as strings.

Both XML and JSON results follow the same outline:

interactiondata

Root element in XML, or anonymous object in JSON

nlmDisclaimer

interactionTypeGroup (array)

Interactions from one data source

sourceDisclaimer

sourceName: Source of interaction data (ONCHigh or DrugBank)

interactionType (array)

comment

minConceptItem

RxNorm concept

rxcui: RxNorm identifier

name: RxNorm concept name

tty: RxNorm concept's term type

interactionPair (array)

Two interactionConcepts

interactionConcept (array of 2)

RxNorm concept and corresponding drug from an interaction-source data set

minConceptItem

RxNorm concept

rxcui: RxNorm identifier

name: RxNorm concept name

tty: RxNorm concept's term type

sourceConceptItem

Drug from the interaction source's data

id: Source's identifier for the drug

name: Source's name for the drug

url: Location of information from the source of interaction data

severity: Severity (if provided by the source)

description

Example: Drug interactions with Rizatriptan (RxCUI=88014) from ONCHigh

XML: https://rxnav.nlm.nih.gov/REST/interaction/interaction?rxcui=88014&sources=ONCHigh

JSON: https://rxnav.nlm.nih.gov/REST/interaction/interaction.json?rxcui=88014&sources=ONCHigh

An XML result is shown below.

<interactiondata>
    <nlmDisclaimer>It is not the intention of NLM to provide specific medical advice, but rather to provide users with information to better understand their health and their medications. NLM urges you to consult with a qualified physician for advice about medications.</nlmDisclaimer>
    <interactionTypeGroup>
        <sourceDisclaimer>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422823/</sourceDisclaimer>
        <sourceName>ONCHigh</sourceName>
        <interactionType>
            <comment>rizatriptan (88014) is resolved to rizatriptan (88014)</comment>
            <minConceptItem>
                <rxcui>88014</rxcui>
                <name>rizatriptan</name>
                <tty>IN</tty>
            </minConceptItem>
            <interactionPair>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>88014</rxcui>
                        <name>rizatriptan</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>NA</id>
                        <name>rizatriptan</name>
                        <url>NA</url>
                    </sourceConceptItem>
                </interactionConcept>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>10734</rxcui>
                        <name>tranylcypromine</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>NA</id>
                        <name>tranylcypromine</name>
                        <url>NA</url>
                    </sourceConceptItem>
                </interactionConcept>
                <severity>high</severity>
                <description>Triptans - monoamine oxidase (MAO) inhibitors</description>
            </interactionPair>
            <interactionPair>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>88014</rxcui>
                        <name>rizatriptan</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>NA</id>
                        <name>rizatriptan</name>
                        <url>NA</url>
                    </sourceConceptItem>
                </interactionConcept>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>6011</rxcui>
                        <name>isocarboxazid</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>NA</id>
                        <name>isocarboxazid</name>
                        <url>NA</url>
                    </sourceConceptItem>
                </interactionConcept>
                <severity>high</severity>
                <description>Triptans - monoamine oxidase (MAO) inhibitors</description>
            </interactionPair>
            ...
        </interactionType>
    </interactionTypeGroup>
</interactiondata>

Example: Drug interactions with Tigecycline (RxCUI=384455) from DrugBank

XML: https://rxnav.nlm.nih.gov/REST/interaction/interaction?rxcui=384455&sources=DrugBank

JSON: https://rxnav.nlm.nih.gov/REST/interaction/interaction.json?rxcui=384455&sources=DrugBank

An XML result is shown below.

<interactiondata>
    <nlmDisclaimer>It is not the intention of NLM to provide specific medical advice, but rather to provide users with information to better understand their health and their medications. NLM urges you to consult with a qualified physician for advice about medications.</nlmDisclaimer>
    <interactionTypeGroup>
        <sourceDisclaimer>DrugBank is intended for educational and scientific research purposes only and you expressly acknowledge and agree that use of DrugBank is at your sole risk. The accuracy of DrugBank information is not guaranteed and reliance on DrugBank shall be at your sole risk. DrugBank is not intended as a substitute for professional medical advice, diagnosis or treatment..[www.drugbank.ca]</sourceDisclaimer>
        <sourceName>DrugBank</sourceName>
        <interactionType>
            <comment>tigecycline (384455) is resolved to tigecycline (384455)</comment>
            <minConceptItem>
                <rxcui>384455</rxcui>
                <name>tigecycline</name>
                <tty>IN</tty>
            </minConceptItem>
            <interactionPair>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>384455</rxcui>
                        <name>tigecycline</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>DB00560</id>
                        <name>Tigecycline</name>
                        <url>https://go.drugbank.com/drugs/DB00560#interactions</url>
                    </sourceConceptItem>
                </interactionConcept>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>1005921</rxcui>
                        <name>ulipristal</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>DB08867</id>
                        <name>Ulipristal</name>
                        <url>https://go.drugbank.com/drugs/DB08867#interactions</url>
                    </sourceConceptItem>
                </interactionConcept>
                <severity>N/A</severity>
                <description>The serum concentration of Ulipristal can be decreased when it is combined with Tigecycline.</description>
            </interactionPair>
            <interactionPair>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>384455</rxcui>
                        <name>tigecycline</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>DB00560</id>
                        <name>Tigecycline</name>
                        <url>https://go.drugbank.com/drugs/DB00560#interactions</url>
                    </sourceConceptItem>
                </interactionConcept>
                <interactionConcept>
                    <minConceptItem>
                        <rxcui>10109</rxcui>
                        <name>streptomycin</name>
                        <tty>IN</tty>
                    </minConceptItem>
                    <sourceConceptItem>
                        <id>DB01082</id>
                        <name>Streptomycin</name>
                        <url>https://go.drugbank.com/drugs/DB01082#interactions</url>
                    </sourceConceptItem>
                </interactionConcept>
                <severity>N/A</severity>
                <description>The risk or severity of neuromuscular blockade can be increased when Tigecycline is combined with Streptomycin.</description>
            </interactionPair>
            ...
        </interactionType>
    </interactionTypeGroup>
</interactiondata>

APIs

Drug Interaction API