Drug Interaction API

The Interaction API is a web service for accessing drug-drug interactions.

Upcoming Changes On or About January 2, 2024:

The Drug-Drug Interaction API will be discontinued on or about January 2, 2024. RxNav's Interactions tab will also be removed.

Currently, the API uses two sources for its interaction information - ONCHigh and DrugBank.

ONCHigh is a list of high-priority drug-drug interactions derived by a panel of experts and contained in a JAMIA article. ONCHigh is updated using CredibleMeds with drugs that have a known risk of Torsades de Pointes (TdP).

DrugBank drug-drug interaction information is drawn (unmodified) from the non-commercial version of the DrugBank database, which does not carry severity information. See the DrugBank license for more information.

The drug-drug interactions are updated monthly, usually on the first Monday of the month.

Use of the API is subject to Terms of Service. No license is needed to use the Interaction API.

DrugBank Disclaimer DrugBank is intended for educational and scientific research purposes only and you expressly acknowledge and agree that use of DrugBank is at your sole risk. The accuracy of DrugBank information is not guaranteed and reliance on DrugBank shall be at your sole risk. DrugBank is not intended as a substitute for professional medical advice, diagnosis or treatment.
Citing DrugBank Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D668-72. 16381955


FunctionREST ResourceDescription
findDrugInteractions/interactionInteractions of an RxNorm drug
findInteractionsFromList/listInteractions between a list of drugs
getInteractionSources/sourcesSources of the interactions
getVersion/versionVersion of the data set(s)